Medical Function of Diclofenac Potassium

Diclofenac Potassium is a new generation of powerful non-steroidal anti-inflammatory drugs, as phenylacetic acid derivatives. The main pharmacological effect is the inhibition of cyclooxygenase, reducing the biosynthesis of prostaglandins, and prostaglandins play an important role in pain, inflammation and fever processes. The following short-term treatment of acute illnesses can be rapid onset, such as post-traumatic pain, inflammation, postoperative inflammation and pain, gynecological pain and inflammation, various pain syndromes spinal diseases, joint and non-joint rheumatism and rheumatoid disease; but also as a serious infectious ENT painful inflammation of adjuvant therapy. But for fever patients simply do not apply. 

When combined with potassium preparations or preparations digoxin, diclofenac may increase plasma concentrations of the two drugs. Various NSAID has a tendency to inhibit the activity of diuretics, and when combined with potassium-sparing diuretics may rise hyperkalemia, and must monitor serum potassium concentrations. When diclofenac potassium and other NSAID or corticosteroid drugs contracts, may increase the incidence of adverse reactions. Large doses of diclofenac potassium (200mg) can transiently inhibit platelet aggregation. In the application of methotrexate therapy with taking this product, may increase the plasma concentration of methotrexate, and its toxicity may also increase due to the impact on renal prostaglandins may increase the nephrotoxicity of cyclosporin.

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