Medical Function of Dabigatran Etexilate

Dabigatran etexilate is at the forefront of a new generation of oral anticoagulant direct thrombin inhibitors (DTIs), for the prevention of non-valvular atrial fibrillation patients with stroke and systemic embolism. Dabigatran etexilate provides effective, predictable and stable anticoagulant effect, while less frequent drug interactions, drug-free food interactions, without routine coagulation monitoring or dose adjustment. 

After oral administration, dabigatran etexilate rapidly and completely converted to dabigatran, which is the product of an active ingredient in plasma. Prodrug dabigatran etexilate is formed by esterase catalyzed hydrolysis is the main active ingredient dabigatran metabolic reactions. The absolute bioavailability of the oral administration of Houdabijia population of about 6.5%. After oral administration in healthy volunteers, the pharmacokinetics of dabigatran in plasma characteristics of the performance of the plasma concentration increased rapidly, from 0.5 to 2.0 hours after administration to peak concentration (Cmax).

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