Pharmacological Effects of Clopidogrel Hydrogen Sulfate

Clopidogrel hydrogen sulfate is white or white crystalline powder; odorless, this product in water, methanol, ethanol or acetic acid dissolved, very slightly soluble in chloroform or acetone; almost insoluble in ethyl acetate 

Clopidogrel also inhibits selective adenosine diphosphate (ADP) to its platelet receptor and the binding of ADP-mediated secondary glycoprotein GPlllb / llla activator complex, thereby inhibiting platelet aggregation, clopidogrel must biotransformation to inhibit platelet aggregation, but have not produced this effect isolated active metabolite. In addition ADP, the clopidogrel reactivate amplification by blocking the release of platelets induced by ADP, inhibition of platelet aggregation induced by other agonists. Clopidogrel does not inhibit phosphodiesterase activity. Clopidogrel by irreversibly modifying the platelet ADP receptors. Platelets exposed to clopidogrel life be affected. The rate of platelet recovery to normal platelet function with about updates. 

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