Capecitabine is a kind that can be converted in vivo to 5-FU antimetabolite fluoropyrimidine carbamate deoxynucleoside drug developed by Roche, trade name Xeloda, capable of inhibiting cell division and interfere with RNA and proteins (protein) synthesis. Suitable for further treatment including paclitaxel and anthracycline chemotherapy ineffective advanced primary or metastatic breast cancer. Mainly used for advanced primary or metastatic breast cancer, colorectal cancer, colon cancer, and treatment of gastric cancer.
Normal cells and tumor cells to 5-FU can be metabolized to 5-fluoro-2-deoxy-uridine monophosphate (FdUMP) and 5-fluoro uridine triphosphate (FUTP). These two kinds of metabolites through cell damage caused by different mechanisms. First, FdUMP and folic acid cofactor N [sup] 5,10 [/ sup] - methylenetetrahydrofolate and thymidylate synthase (TS) to form covalently bound triplicate thereof. This binding inhibition 2'-deoxyuridine [pyrimidine core] nucleotide formation of thymidylate. Thymidylate thymine triphosphate precursors necessary, which is required for DNA synthesis, and therefore less of the compound can inhibit cell division.
Hubei Ocean Biotech Co., Ltd, China pharmaceutical products and APIs supplier, with credible service and the honest management, we have gained good reputation at domestic and abroad market. The main cause is not only for our honesty and service, but more importantly for our quality insurance about the products we offer. That's why customers choose us, our products are rest assured to buy, it is our honesty and service solved customer’s worries. That’s why we could be able to extend our market and serve more people.
If you have more interest in our pharmaceutical raw materials such as Acyclovir China API supplier, please take a view at our site and contact us to get more information.
没有评论:
发表评论