Pharmacological Effects of Captopril

Captopril, a synthetic non-peptide angiotensin-converting enzyme (ACEI) inhibitors, a major role in the renin - angiotensin - aldosterone system (RAA system). RAA system inhibition of angiotensin-converting enzyme (ACEI), angiotensin Ⅰ converting or prevent angiotensin Ⅱ, and can inhibit the secretion of aldosterone, reduce sodium retention. Have significant antihypertensive effect of various types of hypertension and congestive heart failure patients can improve heart function. Antihypertensive effect of different sub-renin hypertensive patients with high renin and normal renin two types; low-renin after the addition of a diuretic antihypertensive effect is also evident. Antihypertensive mechanism of inhibition of angiotensin-converting enzyme activity, reduced angiotensin Ⅱ, relaxation of small arteries and the like. This product has a mild to moderate antihypertensive effect, can reduce peripheral vascular resistance, increased renal blood flow, heart rate is not accompanied by reflex. It can lower blood pressure through the following mechanisms: inhibition of angiotensin converting enzyme, angiotensin I into AngII decrease, resulting in vasodilation; while reducing aldosterone secretion, facilitate natriuresis; also strengthen specific renal vasodilation natriuresis effects; due to the inhibition of hydrolysis of bradykinin, reduce inactivation of bradykinin; moreover still inhibit the formation of angiotensin I in the blood vessels within the tissue and myocardium. It improves heart function in patients with heart failure.

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