Celecoxib is a nonsteroidal anti-inflammatory drugs, in animal models observed to have anti-inflammatory, analgesic and antipyretic. This product is the mechanism through inhibition of cyclooxygenase -2 (COX-2) to inhibit prostaglandin production. And therapeutic concentrations in the human body, the product of the isoenzyme cyclooxygenase - -1 (COX-1) had no inhibitory effect. In animal colon tumor models, celecoxib slowed tumor development and progression.
A single oral dose of celecoxib for about three hours up to maximum plasma concentration. In the fasting state, celebrex celecoxib at doses up to 200mg twice daily, the maximum plasma concentration (Cmax) and area under the curve (AUC) are roughly proportional to dose; dose further increased when this proportional relationship weakened (see food effect). Currently, the research has not been absolute bioavailability. After multiple doses, 5 days to reach steady-state plasma levels.
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