Chlorpheniramine maleate preparations are tablets, injections, also known as chlorpheniramine, antihistamines, anti-allergic effect of this product has played through the H1-receptor antagonist. Mainly used for rhinitis, allergic skin and mucous membranes and ease tears, sneezing, runny nose and other cold symptoms.
This product is in addition to a strong competitive blocking allergy target cells histamine H1 receptors, H1 receptor antagonist through the play anti-allergic effects, it also has anti-M-cholinergic receptors, so the medication Exceptions may dry mouth, constipation, mucus thickens, nasal symptoms such as dry. In addition the drug also has a central role in suppression, so there may be sleepy after taking adverse reactions.
Oral and injectable medicine is absorbed quickly and completely, protein binding rate was 72%. Oral onset time of 15 to 60 minutes, the plasma concentration of 3 to 6 hours up to the peak, intramuscular onset time of 5 to 10 minutes. Half-life of 12 to 15 hours, can be maintained in vivo for 3 to 6 hours. Most of the drug in the body metabolized by the liver, 24 hours after the most excreted by the kidneys, but also through feces, sweat excretion. Lactating women, it can also be excreted through breast milk part.
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