2016年4月18日星期一

Antiviral Drug Of Ribavirin

Ribavirin is a synthetic nucleoside antiviral drugs. In vitro cell culture experiments showed that ribavirin for respiratory syncytial virus (RSV) selective inhibition. It is a prodrug, when the carrier is similar to microbial genetic purine nucleotide RNA, it will interfere with the metabolism of RNA required for viral replication.
Ribavirin is widely distributed in all tissues, including the brain and cerebrospinal fluid. In the pharmacokinetics of the drug ribavirin captured cells, especially red blood cells (RBC), the lack of this enzyme, once it is added kinases, and thus obtain a high concentration of the drug in the form of phosphate phosphate removal the Lord. Most of the kinase activity of the drug to convert active nucleotide form, by adenine kinases. This enzyme is virus-infected cells more active.
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