Clofarabine is a purine nucleoside derivatives, clofarabine effect by inhibiting ribonucleotide reductase, decreasing intracellular reserves of deoxy nucleoside triphosphates, inhibition of DNA synthesis; DNA strand by binding, competitive inhibition of DNA polymerase the DNA chain elongation and repair aborted.
Clofarabine triphosphate composition of these enzymes with affinity similar to or greater than deoxycytidine. Preclinical studies have shown that the repair phase, clofarabine by binding to DNA strands, inhibit DNA repair. Clofarabine 5'-triphosphate compounds can also break the integrity of the mitochondrial membrane, leading to apoptosis mitochondrial protein, cytochrome C, apoptosis-inducing factor release, eventually leading to programmed cell death.
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