Tacrolimus is isolated from streptomyces tsukubaensis in fermentation products, and its chemical structure belong to macrolide antibiotics. As a potent new immunosuppressive agents, mainly through the inhibition release of L-2, the full effect of inhibiting T lymphocytes, 100 times stronger than cyclosporine (CSA). It is the first choice of immune-suppressing drug to liver, heart, kidney and bone marrow transplant patients, it is also the choice of traditional immunosuppressive after transplant’s rejection.
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