Mesalazine dose-dependent manner to inhibit prostaglandin synthesis, reduce the release of PGE2 in human colon mucosa. Furthermore, mesalazine can also inhibit neutrophil lipoxygenase activity. Join mesalazine cultured human colon mucosa cells of two important inflammatory mediators - chemotaxis and leukotriene LTB4 produces dose-response inhibition. When high doses of mesalazine can inhibit certain human neutrophil functions, such as migration, degranulation, phagocytosis and synthetic oxygen free radicals. Furthermore, mesalazine can also play an important role in suppressing inflammation in the platelet activity factor (PAF) synthesis. Inflammation of the intestinal wall connective tissue better. For ulcerative colitis, Crohn's disease and ulcerative proctitis.
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