Colistin Sulfate, also known as Colistin, Polymyxin E, and other enemy elements, white or nearly white powder, odorless, bitter, hygroscopic, soluble in water, slightly soluble in methanol, ethanol, practically insoluble in acetone and ether, water-soluble free base. Stable in PH3-7.5 range. Colistin sulfate produced by the Bacillus polymyxa, Gram-negative bacteria have a strong antibacterial effect, for the treatment of intestinal diseases caused by Gram-negative bacteria, used as feed additives, and there is significant growth-promoting effect. And sulfadiazine combination effect is better.
When contacted with susceptible strains, the chemical structure of a free amino group (positive charge) and bacterial cell membrane phosphate phosphate ester (a negative charge) combination of the increase in membrane permeability, resulting in important intracellular substances such as amino acids , purine, pyrimidine, K +, etc. leakage. It can also affect the function of nuclear matter and the ribosome.
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