Spironolactone is a synthetic compounds, an inefficient diuretics, aldosterone and its structure is similar to aldosterone competitive inhibitor. The role of small tubes in the distal convoluted and collecting duct, blocking the Na + -K + and Na + -H + exchange, the results of Na +, Cl- and water excretion, K +, Mg2 + and H + excretion decreased, the role of Ca2 + and P3- of uncertainty. Since the drug only acts on the distal tubule and collecting duct of the other tubular segments no effect, it is a weak diuretic effect. In addition, the drug aldosterone target organ tubules also play a role outside.
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