Fludarabine structure is similar to Ara-C, in the nucleoside deoxycytidine kinase and other kinases, phosphorylated to triphosphate compound (F-Ara-ATP), inhibition of DNA polymerase activity, thereby preventing DNA synthesis. This product can also be incorporated into DNA, interfering with DNA function. This product nucleotide extension blocking effects of Ara-C is more obvious than the ability to be incorporated into RNA also stronger than Ara-C.
Side Effect:
(1) bone marrow suppression: the dose-limiting toxicity, manifested as neutropenia, anemia.
(2) gastrointestinal reactions: nausea, vomiting, diarrhea, anorexia.
(3) Neurotoxicity: the dose-limiting toxicity, even lower doses are also visible neurotoxicity 20%, often irreversible.
(4) occasionally tumor lysis symptoms and lung toxicity.
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