Norcantharidin has destruction or inhibition of proliferation for liver cancer, esophageal squamous cell carcinoma cell lines, cancer cells can be improved respiratory control ratio and lysosomal enzyme activity, interfere with cell division and inhibit DNA synthesis. No inhibitory effect on bone marrow cells, white blood cells and can increase.
After absorption of a higher concentration of the drug in the liver, kidney, stomach, intestine carcinoma. 15 minutes after administration of liver cancer tissue reached a peak concentration after 6 hours was significantly decreased, mostly excreted by the kidneys within 24 hours, accumulate little.
Clinical for liver cancer, esophageal cancer, gastric cardia and other white blood cells as well as hypothyroidism, can also be used as a premedication or in combination with chemotherapy, in combination with other chemotherapy drugs can improve efficacy, reduce side effects. For hepatitis B is also effective.
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