Cilnidipine is a lipophilic dihydropyridine calcium antagonist, capable of binding sites on the dihydropyridine vascular smooth muscle cells L-type calcium channels, inhibition of Ca2 + through L-type calcium channel transmembrane flow, thus relaxation expansion of vascular smooth muscle, played a hypotensive effect. It can also inhibit the sympathetic nerve endings release noradrenaline and sympathetic nerve activity through the inhibition of Ca2+ through transmembrane N-type calcium channels on the flow sympathetic cell membrane.
Based clinical studies have shown that while the expansion cilnidipine glomerular afferent and efferent arterioles, reducing the glomerular capsule pressure, with renal protective effect to improve renal function and reduce proteinuria excretion rates. Cilnidipine also has antioxidant, inhibiting vascular smooth muscle cell proliferation, improve diastolic left ventricular systolic function, improve left ventricular hypertrophy and improve the role of insulin resistance. It may improve vascular endothelial dilatation function, improve coronary blood flow, improve cerebral blood flow, improve arterial stiffness, reduce the risk of myocardial infarct size and reperfusion arrhythmias, angina pectoris control.
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