Pramipexole Hydrochloride tablets are used in the treatment of idiopathic Parkinson's disease signs and symptoms, alone (without levodopa) or in combination with levodopa. For example, the efficacy of levodopa later in the disease gradually weakened or there (end of dose phenomenon or "switch" fluctuations) changes and volatility, the FDA should require.
This product is a dopamine receptor agonists, dopamine D2 receptor subfamily combined with high selectivity and specificity, and has full intrinsic activity, on which the D3 receptor affinity priority. Pramipexole through the excitement of striatal dopamine receptors to reduce dyskinesia in patients with Parkinson's. Animal trials have shown that pramipexole inhibits the synthesis of dopamine release and renew.
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