Clotrimazole belongs to azoles antifungal, Candida albicans can inhibit the process of its transformation from Bacillus invasive hyphae. Clotrimazole with broad-spectrum antifungal activity against Epidermophyton, Trichophyton, aspergillosis, Cryptococcus and Candida species have good antibacterial effect on Sporothrix, dermatitis blastomycosis, crude ball Microsporum, cellular tissue pulp genus, also have some antibacterial activity.
Clotrimazole activity by interfering cytochrome P-450, thus inhibiting the biosynthesis of ergosterol and other sterols fungi, fungal cell membrane damage and change its permeability, resulting in important intracellular material leakage. Biosynthesis inhibit fungal triglyceride and phospholipid, also inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrogen peroxide causes cell submicroscopic structural degeneration and necrosis.
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